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A sixteen-year-old boy named Joonha discovers an unusual condition after a routine bathroom visit, where he realizes he is missing a body part he previously took for granted and faints. While semi-conscious, he learns the shocking truth about his family: after puberty, their chromosomes mutate, causing a complete physical transformation into the opposite sex. This means his father was originally a woman living as a man. Joonha must now adapt to life as a woman after sixteen years of living as a man. He faces uncertainty about how his childhood friend Jinhoo and the girl he has feelings for, Heewon, will react to the revelation.