第1話: カトリエルは、家族が不審な状況で姿を消したサイモン・ライトの呪われた家を調査する。

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Katrielle Layton, daughter of the famous Professor Layton who has solved countless puzzles around the world, receives a strange request from Simon Light. "It seems the house I bought was cursed, and my whole family has disappeared". His wife and two daughters, and even Inspector Aspoirot, who was investigating the case, vanished, so Simon is scared that he might be the next. Kat goes to Simon's house with her assistant Noah and the talking dog Sherl, but there are some uncomfortable feelings...! What are the torn bonds between family members and the secrets of the house? Can Kat really have 'Any mystery solved', as the motto of her agency says? (Source: Layton anime official website)