Tập 1: Katrielle điều tra ngôi nhà bị nguyền rủa của Simon Light, nơi gia đình anh biến mất trong những hoàn cảnh bí ẩn.

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Katrielle Layton, daughter of the famous Professor Layton who has solved countless puzzles around the world, receives a strange request from Simon Light. "It seems the house I bought was cursed, and my whole family has disappeared". His wife and two daughters, and even Inspector Aspoirot, who was investigating the case, vanished, so Simon is scared that he might be the next. Kat goes to Simon's house with her assistant Noah and the talking dog Sherl, but there are some uncomfortable feelings...! What are the torn bonds between family members and the secrets of the house? Can Kat really have 'Any mystery solved', as the motto of her agency says? (Source: Layton anime official website)