Ep. 45: Joe and Jose engage in a direct confrontation within the boxing ring.
Aired on August 17, 1981

Joe and Jose finally face off in the ring. With his impenetrable defense, Jose dodges Joe's attacks while hitting him with his own punches. After receiving countless blows and unable to land a meaningful punch against Jose.
Episodes
- Ep. 41 · Jose arrives in Japan shortly after the bout confirmation
- Ep. 42 · Yoko Consults Dr. Kinninski Regarding Joe's Potential Punch-Drunk Syndrome
- Ep. 43 · Joe trains at a mountain lodge to hide his health from Danpei while Yoko tracks him down.
- Ep. 44 · Yoko Urges Joe to Cancel Title Match Before He Suffers Carlos' Fate
- Ep. 45 · Joe and Jose engage in a direct confrontation within the boxing ring.
- Ep. 46 · Joe Refuses to Give Up Despite His Severe Vision Impairment
- Ep. 47 · Jose's victory seems certain, but Joe adapts to the corkscrew punch and fights on.