Ep. 22: The team combines their mechs into Arc-Gurren-Lagann to halt the Human Annihilation System
Aired on August 26, 2007

The Gurren-Lagann and the Arc-Gurren unite to create the colossal Arc-Gurren-Lagann. This combined unit is deployed with the specific objective of stopping the Human Annihilation System. The narrative focuses on this mechanical fusion and the subsequent effort to prevent the system from executing its destructive function against humanity.
Episodes
- Ep. 18 · Simon searches for Nia after the Anti-Spirals' first attack while Rossiu completes his secret project.
- Ep. 19 · Rossiu arrests Simon to calm public opinion before deploying him against the Anti-Spirals.
- Ep. 20 · Simon meets Viral in prison while Rossiu's emergency plan consequences are revealed
- Ep. 21 · Yoko returns to Teppelin after a year teaching, reuniting with Simon to launch into space with Viral.
- Ep. 22 · The team combines their mechs into Arc-Gurren-Lagann to halt the Human Annihilation System
- Ep. 23 · Team Dai-Gurren prepares for the final battle while Rossiu goes missing
- Ep. 24 · Team Dai-Gurren traverses dimensions guided by Simon and Nia's bond to find the Anti-Spirals' home.
- Ep. 25 · Team Dai-Gurren faces despair as another member sacrifices himself to save the group.
- Ep. 26 · Simon and friends battle the enemy using Super Galactic Gurren-Lagann after Kamina's reappearance